| 7. Round | 03/09/2022 | Colchester United | - | Hartlepool United | 1:1 | ||||
| 9. Round | 13/09/2022 | Walsall FC | - | Colchester United | 1:1 |  |
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| 10. Round | 17/09/2022 | Colchester United | - | Grimsby Town | 0:1 | ||||
| 11. Round | 24/09/2022 | Colchester United | - | Rochdale AFC | 0:1 | ||||
| 12. Round | 01/10/2022 | AFC Wimbledon | - | Colchester United | 2:1 |  |
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| 14. Round | 08/10/2022 | Colchester United | - | Harrogate Town | 2:1 | |
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| 20. Round | 03/12/2022 | Mansfield Town | - | Colchester United | 2:1 | ||||
| 21. Round | 10/12/2022 | Sutton United | - | Colchester United | 1:0 | ||||
| 30. Round | 04/02/2023 | Colchester United | - | Barrow AFC | 1:1 | |
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| 31. Round | 11/02/2023 | Grimsby Town | - | Colchester United | 0:1 | ||||
| 32. Round | 14/02/2023 | Colchester United | - | Walsall FC | 0:0 | ||||
| 33. Round | 18/02/2023 | Carlisle United | - | Colchester United | 1:0 | ||||
| 34. Round | 25/02/2023 | Colchester United | - | Northampton Town | 0:1 |
England
