| 33. Round | 19/02/2011 | Torquay United | - | Southend United | 1:1 | ||||
| 22. Round | 22/02/2011 | Southend United | - | Barnet FC | 2:1 | ||||
| 35. Round | 05/03/2011 | Morecambe FC | - | Southend United | 2:1 | ||||
| 37. Round | 12/03/2011 | Lincoln City | - | Southend United | 2:1 | ||||
| 23. Round | 15/03/2011 | Crewe Alexandra | - | Southend United | 1:0 | ||||
| 39. Round | 26/03/2011 | Stockport County | - | Southend United | 2:1 |  |
 |
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| 32. Round | 05/04/2011 | Accrington Stanley | - | Southend United | 3:1 | ||||
| 42. Round | 15/04/2011 | Southend United | - | Bradford City | 4:0 | ||||
| 46. Round | 07/05/2011 | Wycombe Wanderers | - | Southend United | 3:1 |
England