| 6. Round | 04/09/2021 | Exeter City | - | Forest Green Rovers | 0:0 | ||||
| 7. Round | 11/09/2021 | Scunthorpe United | - | Exeter City | 0:4 | ||||
| 8. Round | 18/09/2021 | Exeter City | - | Sutton United | 2:0 | ||||
| 9. Round | 25/09/2021 | Hartlepool United | - | Exeter City | 1:1 | ||||
| 12. Round | 16/10/2021 | Exeter City | - | Newport County | 2:2 | ||||
| 13. Round | 19/10/2021 | Crawley Town | - | Exeter City | 1:3 | ||||
| 14. Round | 23/10/2021 | Exeter City | - | Mansfield Town | 2:1 | ||||
| 20. Round | 07/12/2021 | Exeter City | - | Northampton Town | 1:2 | ||||
| 21. Round | 11/12/2021 | Exeter City | - | Tranmere Rovers | 0:1 | ||||
| 24. Round | 04/01/2022 | Forest Green Rovers | - | Exeter City | 0:0 | ||||
| 29. Round | 29/01/2022 | Exeter City | - | Hartlepool United | 0:0 | ||||
| 31. Round | 08/02/2022 | Exeter City | - | Leyton Orient | 1:0 | ||||
| 37. Round | 15/03/2022 | Exeter City | - | Crawley Town | 2:1 | ||||
| 38. Round | 19/03/2022 | Oldham Athletic | - | Exeter City | 0:2 |  |
Switzerland