| 1. Round | 07/08/2010 | Southampton FC | - | Plymouth Argyle | 0:1 | ||||
| 2. Round | 15/09/2010 | Milton Keynes Dons | - | Southampton FC | 2:0 | ||||
| 7. Round | 18/09/2010 | Southampton FC | - | Colchester United | 0:0 | ||||
| 8. Round | 25/09/2010 | Sheffield Wednesday | - | Southampton FC | 0:1 | ||||
| 11. Round | 09/10/2010 | Southampton FC | - | Tranmere Rovers | 2:0 | ||||
| 17. Round | 20/11/2010 | Southampton FC | - | Peterborough United | 4:1 | ||||
| 18. Round | 23/11/2010 | Southampton FC | - | Brighton & Hove Albion | 0:0 |
England