| 4. Round | 11/09/2021 | Leeds United U23 | - | West Ham United U23 | 2:2 | ||||
| 5. Round | 19/09/2021 | Liverpool FC U23 | - | Leeds United U23 | 0:4 | ||||
| 6. Round | 24/09/2021 | Leeds United U23 | - | Blackburn Rovers U23 | 4:4 | ||||
| 8. Round | 18/10/2021 | Everton FC U23 | - | Leeds United U23 | 4:2 | ||||
| 9. Round | 22/10/2021 | Leeds United U23 | - | Brighton & Hove Albion U23 | 1:1 | ||||
| 10. Round | 29/10/2021 | Leeds United U23 | - | Arsenal FC U23 | 2:4 | ||||
| 11. Round | 06/11/2021 | Manchester United U23 | - | Leeds United U23 | 3:2 |  |
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| 12. Round | 19/11/2021 | Leeds United U23 | - | Chelsea FC U23 | 1:3 | ||||
| 13. Round | 29/11/2021 | Manchester City U23 | - | Leeds United U23 | 3:2 | ||||
| 18. Round | 24/01/2022 | Blackburn Rovers U23 | - | Leeds United U23 | 4:0 | |
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| 20. Round | 15/04/2022 | Brighton & Hove Albion U23 | - | Leeds United U23 | 1:0 | ||||
| 26. Round | 29/04/2022 | Arsenal FC U23 | - | Leeds United U23 | 1:1 | |
England