| 1. Round | 14/08/2021 | Watford FC | - | Aston Villa | 3:2 | ||||
| 4. Round | 11/09/2021 | Chelsea FC | - | Aston Villa | 3:0 | ||||
| 5. Round | 18/09/2021 | Aston Villa | - | Everton FC | 3:0 |  |
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| 9. Round | 22/10/2021 | Arsenal FC | - | Aston Villa | 3:1 | ||||
| 10. Round | 31/10/2021 | Aston Villa | - | West Ham United | 1:4 | ||||
| 11. Round | 05/11/2021 | Southampton FC | - | Aston Villa | 1:0 | ||||
| 12. Round | 20/11/2021 | Aston Villa | - | Brighton & Hove Albion | 2:0 | ||||
| 13. Round | 27/11/2021 | Crystal Palace | - | Aston Villa | 1:2 | ||||
| 14. Round | 01/12/2021 | Aston Villa | - | Manchester City | 1:2 | ||||
| 25. Round | 13/02/2022 | Newcastle United | - | Aston Villa | 1:0 | |
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| 26. Round | 19/02/2022 | Aston Villa | - | Watford FC | 0:1 | ||||
| 28. Round | 05/03/2022 | Aston Villa | - | Southampton FC | 4:0 | ||||
| 29. Round | 13/03/2022 | West Ham United | - | Aston Villa | 2:1 | ||||
| 30. Round | 19/03/2022 | Aston Villa | - | Arsenal FC | 0:1 | ||||
| 31. Round | 02/04/2022 | Wolverhampton Wanderers | - | Aston Villa | 2:1 | ||||
| 32. Round | 09/04/2022 | Aston Villa | - | Tottenham Hotspur | 0:4 | ||||
| 34. Round | 23/04/2022 | Leicester City | - | Aston Villa | 0:0 | |
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| 35. Round | 30/04/2022 | Aston Villa | - | Norwich City | 2:0 |
Jamaica
