| 7. Round | 03/09/2022 | Newport County | - | Grimsby Town | 0:2 | ||||
| 9. Round | 13/09/2022 | Grimsby Town | - | Gillingham FC | 1:1 | ||||
| 10. Round | 17/09/2022 | Colchester United | - | Grimsby Town | 0:1 | ||||
| 11. Round | 24/09/2022 | Grimsby Town | - | Swindon Town | 1:2 | ||||
| 4. Round | 27/09/2022 | Grimsby Town | - | Carlisle United | 1:2 | ||||
| 12. Round | 01/10/2022 | Salford City | - | Grimsby Town | 1:1 |  |
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| 16. Round | 22/10/2022 | Grimsby Town | - | Bradford City | 0:0 | ||||
| 13. Round | 25/10/2022 | Barrow AFC | - | Grimsby Town | 1:0 | ||||
| 17. Round | 29/10/2022 | Hartlepool United | - | Grimsby Town | 2:1 | ||||
| 18. Round | 12/11/2022 | Grimsby Town | - | Doncaster Rovers | 1:3 |
England