| 1. Round | 07/08/2021 | Scunthorpe United | - | Swindon Town | 1:3 | ||||
| 2. Round | 14/08/2021 | Rochdale AFC | - | Scunthorpe United | 0:0 | ||||
| 3. Round | 17/08/2021 | Walsall FC | - | Scunthorpe United | 1:1 | ||||
| 4. Round | 21/08/2021 | Scunthorpe United | - | Sutton United | 1:1 |  |
|||
| 5. Round | 28/08/2021 | Scunthorpe United | - | Tranmere Rovers | 1:0 | ||||
| 6. Round | 04/09/2021 | Northampton Town | - | Scunthorpe United | 2:0 | |
|||
| 7. Round | 11/09/2021 | Scunthorpe United | - | Exeter City | 0:4 | ||||
| 11. Round | 09/10/2021 | Harrogate Town | - | Scunthorpe United | 6:1 |  |
|||
| 13. Round | 19/10/2021 | Barrow AFC | - | Scunthorpe United | 1:1 | ||||
| 14. Round | 23/10/2021 | Scunthorpe United | - | Crawley Town | 2:1 | ||||
| 15. Round | 30/10/2021 | Colchester United | - | Scunthorpe United | 2:1 | |
|||
| 18. Round | 23/11/2021 | Scunthorpe United | - | Leyton Orient | 1:1 | |
|||
| 19. Round | 27/11/2021 | Scunthorpe United | - | Bradford City | 1:1 | ||||
| 24. Round | 22/02/2022 | Scunthorpe United | - | Northampton Town | 0:0 |
Northern Ireland
England