| 1. Round | 07/08/2021 | Preston North End | - | Hull City | 1:4 | ||||
| 2. Round | 14/08/2021 | Reading FC | - | Preston North End | 2:1 | ||||
| 3. Round | 17/08/2021 | Huddersfield Town | - | Preston North End | 1:0 |  |
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| 11. Round | 02/10/2021 | Queens Park Rangers | - | Preston North End | 3:2 | ||||
| 20. Round | 27/11/2021 | Preston North End | - | Fulham FC | 1:1 | ||||
| 21. Round | 04/12/2021 | Blackburn Rovers | - | Preston North End | 1:0 | ||||
| 23. Round | 01/02/2022 | Millwall FC | - | Preston North End | 0:0 | ||||
| 33. Round | 19/02/2022 | Preston North End | - | Reading FC | 2:3 | ||||
| 34. Round | 22/02/2022 | Preston North End | - | Nottingham Forest | 0:0 | ||||
| 35. Round | 26/02/2022 | Coventry City | - | Preston North End | 1:1 |  |
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| 37. Round | 12/03/2022 | Cardiff City | - | Preston North End | 0:0 | ||||
| 40. Round | 02/04/2022 | Derby County | - | Preston North End | 1:0 |  |
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| 43. Round | 19/04/2022 | Fulham FC | - | Preston North End | 3:0 | ||||
| 45. Round | 30/04/2022 | Barnsley FC | - | Preston North End | 1:3 | ||||
| 46. Round | 07/05/2022 | Preston North End | - | Middlesbrough FC | 4:1 |
Scotland