| 1. Round | 07/08/2021 | Stoke City | - | Reading FC | 3:2 |  |
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| 2. Round | 14/08/2021 | Reading FC | - | Preston North End | 2:1 | ||||
| 3. Round | 17/08/2021 | Reading FC | - | Bristol City | 2:3 | |
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| 4. Round | 21/08/2021 | Coventry City | - | Reading FC | 2:1 | ||||
| 5. Round | 28/08/2021 | Huddersfield Town | - | Reading FC | 4:0 | ||||
| 6. Round | 11/09/2021 | Reading FC | - | Queens Park Rangers | 3:3 | ||||
| 7. Round | 14/09/2021 | Reading FC | - | Peterborough United | 3:1 | ||||
| 11. Round | 02/10/2021 | Cardiff City | - | Reading FC | 0:1 | ||||
| 12. Round | 16/10/2021 | Reading FC | - | Barnsley FC | 1:0 | ||||
| 13. Round | 20/10/2021 | Reading FC | - | Blackpool FC | 2:3 | ||||
| 14. Round | 23/10/2021 | Blackburn Rovers | - | Reading FC | 2:0 | ||||
| 15. Round | 30/10/2021 | Reading FC | - | AFC Bournemouth | 0:2 | ||||
| 16. Round | 02/11/2021 | Millwall FC | - | Reading FC | 1:0 | ||||
| 17. Round | 06/11/2021 | Birmingham City | - | Reading FC | 1:2 | ||||
| 18. Round | 20/11/2021 | Reading FC | - | Nottingham Forest | 1:1 | |
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| 19. Round | 23/11/2021 | Reading FC | - | Sheffield United | 0:1 | ||||
| 22. Round | 11/12/2021 | West Bromwich Albion | - | Reading FC | 1:0 |
England
