| 1. Round | 16/08/2021 | Derby County U23 | - | Brighton & Hove Albion U23 | 0:2 |  |
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| 3. Round | 27/08/2021 | Derby County U23 | - | Leeds United U23 | 2:3 | ||||
| 4. Round | 10/09/2021 | Everton FC U23 | - | Derby County U23 | 1:0 | ||||
| 5. Round | 20/09/2021 | Derby County U23 | - | West Ham United U23 | 3:1 | ||||
| 6. Round | 27/09/2021 | Tottenham Hotspur U23 | - | Derby County U23 | 3:1 | ||||
| 7. Round | 02/10/2021 | Manchester City U23 | - | Derby County U23 | 1:0 | |
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| 8. Round | 16/10/2021 | Chelsea FC U23 | - | Derby County U23 | 2:0 | ||||
| 11. Round | 05/11/2021 | Derby County U23 | - | Blackburn Rovers U23 | 6:0 | ||||
| 24. Round | 04/04/2022 | Brighton & Hove Albion U23 | - | Derby County U23 | 5:1 | |
England