| 11. Round | 05/11/2021 | Derby County U23 | - | Blackburn Rovers U23 | 6:0 | ||||
| 12. Round | 19/11/2021 | Derby County U23 | - | Manchester United U23 | 1:1 |  |
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| 13. Round | 26/11/2021 | Arsenal FC U23 | - | Derby County U23 | 3:5 | ||||
| 14. Round | 03/12/2021 | Derby County U23 | - | Chelsea FC U23 | 3:1 | |
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| 16. Round | 10/01/2022 | Derby County U23 | - | Liverpool FC U23 | 0:1 | ||||
| 17. Round | 17/01/2022 | Leeds United U23 | - | Derby County U23 | 2:0 | ||||
| 18. Round | 21/01/2022 | Derby County U23 | - | Arsenal FC U23 | 1:1 | ||||
| 19. Round | 07/02/2022 | Derby County U23 | - | Manchester City U23 | 0:5 | ||||
| 20. Round | 21/02/2022 | Derby County U23 | - | Everton FC U23 | 0:2 | ||||
| 21. Round | 25/02/2022 | Manchester United U23 | - | Derby County U23 | 5:2 | ||||
| 22. Round | 13/03/2022 | Derby County U23 | - | Leicester City U23 | 0:0 | ||||
| 23. Round | 21/03/2022 | Blackburn Rovers U23 | - | Derby County U23 | 2:1 | ||||
| 24. Round | 04/04/2022 | Brighton & Hove Albion U23 | - | Derby County U23 | 5:1 | ||||
| 2. Round | 15/04/2022 | Leicester City U23 | - | Derby County U23 | 2:1 | ||||
| 15. Round | 09/05/2022 | Crystal Palace U23 | - | Derby County U23 | 3:1 |
England