| 21. Round | 28/01/2012 | Lille OSC | - | AS Saint-Étienne | 3:0 | ||||
| 23. Round | 12/02/2012 | Lille OSC | - | Girondins Bordeaux | 4:5 | ||||
| 22. Round | 22/02/2012 | FC Sochaux | - | Lille OSC | 0:1 | ||||
| 25. Round | 26/02/2012 | Stade Rennais | - | Lille OSC | 1:1 |  |
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| 26. Round | 03/03/2012 | Lille OSC | - | AJ Auxerre | 2:2 | ||||
| 27. Round | 10/03/2012 | Olympique Lyonnais | - | Lille OSC | 2:1 | ||||
| 28. Round | 18/03/2012 | Lille OSC | - | Valenciennes FC | 4:0 | ||||
| 29. Round | 24/03/2012 | Évian Thonon Gaillard | - | Lille OSC | 0:3 | ||||
| 30. Round | 01/04/2012 | Lille OSC | - | Toulouse FC | 2:1 | ||||
| 31. Round | 07/04/2012 | Stade Brestois 29 | - | Lille OSC | 3:1 | ||||
| 32. Round | 15/04/2012 | Lille OSC | - | AC Ajaccio | 4:1 | ||||
| 33. Round | 21/04/2012 | Dijon FCO | - | Lille OSC | 0:2 | ||||
| 34. Round | 29/04/2012 | Lille OSC | - | Paris Saint-Germain | 2:1 | ||||
| 36. Round | 07/05/2012 | Lille OSC | - | SM Caen | 3:0 | ||||
| 37. Round | 13/05/2012 | Montpellier HSC | - | Lille OSC | 1:0 | ||||
| 38. Round | 20/05/2012 | Lille OSC | - | AS Nancy Lorraine | 4:1 |
France
