| 6. Round | 11/09/2021 | Blackburn Rovers | - | Luton Town | 2:2 |  |
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| 7. Round | 15/09/2021 | Bristol City | - | Luton Town | 1:1 | ||||
| 8. Round | 18/09/2021 | Luton Town | - | Swansea City | 3:3 | |
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| 9. Round | 25/09/2021 | AFC Bournemouth | - | Luton Town | 2:1 | ||||
| 10. Round | 29/09/2021 | Luton Town | - | Coventry City | 5:0 | |
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| 11. Round | 02/10/2021 | Luton Town | - | Huddersfield Town | 0:0 | ||||
| 14. Round | 23/10/2021 | Luton Town | - | Hull City | 1:0 | ||||
| 24. Round | 25/01/2022 | Luton Town | - | Bristol City | 2:1 |  |
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| 29. Round | 29/01/2022 | Luton Town | - | Blackburn Rovers | 0:0 | ||||
| 25. Round | 01/02/2022 | Swansea City | - | Luton Town | 0:1 | |
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| 26. Round | 08/03/2022 | Coventry City | - | Luton Town | 0:1 | ||||
| 38. Round | 16/03/2022 | Luton Town | - | Preston North End | 4:0 | |
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| 39. Round | 19/03/2022 | Hull City | - | Luton Town | 1:3 |
England