| 1. Round | 07/08/2021 | Bristol City | - | Blackpool FC | 1:1 | ||||
| 2. Round | 14/08/2021 | Blackpool FC | - | Cardiff City | 0:2 | ||||
| 3. Round | 17/08/2021 | Blackpool FC | - | Coventry City | 0:1 | ||||
| 4. Round | 21/08/2021 | AFC Bournemouth | - | Blackpool FC | 2:2 |  |
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| 5. Round | 28/08/2021 | Millwall FC | - | Blackpool FC | 2:1 | ||||
| 6. Round | 11/09/2021 | Blackpool FC | - | Fulham FC | 1:0 | |
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| 7. Round | 14/09/2021 | Blackpool FC | - | Huddersfield Town | 0:3 | ||||
| 8. Round | 18/09/2021 | Middlesbrough FC | - | Blackpool FC | 1:2 | ||||
| 9. Round | 25/09/2021 | Blackpool FC | - | Barnsley FC | 1:0 | ||||
| 10. Round | 28/09/2021 | Hull City | - | Blackpool FC | 1:1 | |
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| 11. Round | 02/10/2021 | Blackpool FC | - | Blackburn Rovers | 2:1 | ||||
| 12. Round | 16/10/2021 | Nottingham Forest | - | Blackpool FC | 2:1 | ||||
| 15. Round | 30/10/2021 | Sheffield United | - | Blackpool FC | 0:1 | ||||
| 16. Round | 03/11/2021 | Blackpool FC | - | Stoke City | 0:1 | ||||
| 28. Round | 22/01/2022 | Blackpool FC | - | Millwall FC | 1:0 | |
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| 45. Round | 30/04/2022 | Blackpool FC | - | Derby County | 0:2 | ||||
| 46. Round | 07/05/2022 | Peterborough United | - | Blackpool FC | 5:0 |
England
