| 27. Round | 15/01/2022 | Exeter City | - | Scunthorpe United | 2:0 | ||||
| 28. Round | 22/01/2022 | Scunthorpe United | - | Newport County | 0:1 | ||||
| 22. Round | 25/01/2022 | Scunthorpe United | - | Bristol Rovers | 2:3 | ||||
| 29. Round | 29/01/2022 | Port Vale FC | - | Scunthorpe United | 1:0 | ||||
| 32. Round | 12/02/2022 | Swindon Town | - | Scunthorpe United | 3:0 | ||||
| 35. Round | 05/03/2022 | Crawley Town | - | Scunthorpe United | 0:0 | ||||
| 36. Round | 12/03/2022 | Scunthorpe United | - | Colchester United | 1:3 |  |
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| 38. Round | 19/03/2022 | Salford City | - | Scunthorpe United | 5:1 | ||||
| 42. Round | 15/04/2022 | Leyton Orient | - | Scunthorpe United | 3:0 | ||||
| 43. Round | 18/04/2022 | Scunthorpe United | - | Stevenage FC | 1:1 | ||||
| 44. Round | 23/04/2022 | Bradford City | - | Scunthorpe United | 2:1 | ||||
| 45. Round | 30/04/2022 | Scunthorpe United | - | Hartlepool United | 1:1 | ||||
| 46. Round | 07/05/2022 | Bristol Rovers | - | Scunthorpe United | 7:0 |
England
Scotland