| 4. Round | 26/08/2022 | Middlesbrough FC U21 | - | Stoke City U21 | 4:1 | ||||
| 6. Round | 18/09/2022 | Stoke City U21 | - | Aston Villa U21 | 3:3 | ||||
| 7. Round | 30/09/2022 | Leeds United U21 | - | Stoke City U21 | 4:0 |  |
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| 8. Round | 09/10/2022 | Stoke City U21 | - | Norwich City U21 | 2:2 | ||||
| 5. Round | 17/10/2022 | Nottingham Forest U21 | - | Stoke City U21 | 4:1 | ||||
| 9. Round | 23/10/2022 | Stoke City U21 | - | Sunderland AFC U21 | 2:3 | ||||
| 15. Round | 10/02/2023 | Aston Villa U21 | - | Stoke City U21 | 1:0 | ||||
| 16. Round | 20/02/2023 | Stoke City U21 | - | Middlesbrough FC U21 | 1:2 | ||||
| 17. Round | 24/02/2023 | Stoke City U21 | - | Newcastle United U21 | 2:2 | ||||
| 18. Round | 06/03/2023 | Sunderland AFC U21 | - | Stoke City U21 | 4:1 | ||||
| 19. Round | 20/03/2023 | Derby County U21 | - | Stoke City U21 | 1:6 | ||||
| 20. Round | 17/04/2023 | Stoke City U21 | - | Leeds United U21 | 1:1 |  |
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| 22. Round | 24/04/2023 | Stoke City U21 | - | West Bromwich Albion U21 | 0:0 |
England