| 1. Round | 16/08/2021 | Newcastle United U23 | - | Reading FC U23 | 1:1 |  |
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| 2. Round | 23/08/2021 | Reading FC U23 | - | Wolverhampton Wanderers U23 | 3:0 | |
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| 3. Round | 29/08/2021 | Stoke City U23 | - | Reading FC U23 | 1:2 |  |
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| 4. Round | 12/09/2021 | Reading FC U23 | - | Nottingham Forest U23 | 0:2 | ||||
| 5. Round | 20/09/2021 | Reading FC U23 | - | Norwich City U23 | 3:3 | |
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| 6. Round | 27/09/2021 | Burnley FC U23 | - | Reading FC U23 | 3:1 | ||||
| 7. Round | 04/10/2021 | Reading FC U23 | - | Birmingham City U23 | 1:1 | ||||
| 9. Round | 25/10/2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
| 10. Round | 01/11/2021 | Reading FC U23 | - | Sunderland AFC U23 | 0:3 | |
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| 12. Round | 22/11/2021 | West Bromwich Albion U23 | - | Reading FC U23 | 1:1 | |
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| 14. Round | 03/12/2021 | Norwich City U23 | - | Reading FC U23 | 5:2 | |
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| 16. Round | 10/01/2022 | Sunderland AFC U23 | - | Reading FC U23 | 2:0 | ||||
| 19. Round | 07/02/2022 | Reading FC U23 | - | Stoke City U23 | 1:1 | ||||
| 20. Round | 21/02/2022 | Nottingham Forest U23 | - | Reading FC U23 | 7:0 | ||||
| 15. Round | 06/03/2022 | Birmingham City U23 | - | Reading FC U23 | 0:0 | |
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| 23. Round | 20/03/2022 | Southampton FC U23 | - | Reading FC U23 | 2:1 |
England