| 1. Round | 28/07/2000 | Nîmes Olympique | - | FC Sochaux | 3:3 |  |
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| 6. Round | 28/08/2000 | AS Nancy Lorraine | - | Nîmes Olympique | 3:1 |  |
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| 8. Round | 05/09/2000 | Stade Lavallois | - | Nîmes Olympique | 3:1 | |
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| 9. Round | 08/09/2000 | Nîmes Olympique | - | US Créteil-Lusitanos | 2:1 | ||||
| 10. Round | 15/09/2000 | OGC Nice | - | Nîmes Olympique | 1:2 | ||||
| 12. Round | 29/09/2000 | Nîmes Olympique | - | SM Caen | 1:2 | ||||
| 13. Round | 06/10/2000 | Chamois Niortais | - | Nîmes Olympique | 1:1 | ||||
| 17. Round | 27/10/2000 | Le Mans UC 72 | - | Nîmes Olympique | 1:1 | ||||
| 18. Round | 03/11/2000 | Nîmes Olympique | - | Angers SCO | 3:0 | ||||
| 19. Round | 10/11/2000 | AS Cannes | - | Nîmes Olympique | 1:1 | |
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| 15. Round | 13/11/2000 | AC Ajaccio | - | Nîmes Olympique | 1:0 | ||||
| 20. Round | 17/11/2000 | Nîmes Olympique | - | FC Lorient | 1:2 | ||||
| 21. Round | 29/11/2000 | Montpellier HSC | - | Nîmes Olympique | 3:1 | |
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| 22. Round | 02/12/2000 | Nîmes Olympique | - | Havre AC | 2:2 | ||||
| 24. Round | 20/12/2000 | Nîmes Olympique | - | AS Nancy Lorraine | 1:2 | ||||
| 25. Round | 12/01/2001 | ES Wasquehal | - | Nîmes Olympique | 1:1 |
Senegal