| 1. Round | 07/08/2021 | Carlisle United | - | Colchester United | 0:0 | ||||
| 2. Round | 14/08/2021 | Swindon Town | - | Carlisle United | 1:2 | ||||
| 4. Round | 21/08/2021 | Carlisle United | - | Leyton Orient | 1:1 | ||||
| 6. Round | 04/09/2021 | Carlisle United | - | Salford City | 2:1 | ||||
| 9. Round | 25/09/2021 | Sutton United | - | Carlisle United | 4:0 |  |
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| 15. Round | 30/10/2021 | Northampton Town | - | Carlisle United | 3:0 | ||||
| 18. Round | 23/11/2021 | Carlisle United | - | Harrogate Town | 0:2 | ||||
| 19. Round | 27/11/2021 | Carlisle United | - | Walsall FC | 1:0 |
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