| 3. Round | 28/08/2021 | Norwich City | - | Leicester City | 1:2 |  |
 |
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| 4. Round | 11/09/2021 | Leicester City | - | Manchester City | 0:1 | ||||
| 7. Round | 03/10/2021 | Crystal Palace | - | Leicester City | 2:2 | ||||
| 12. Round | 20/11/2021 | Leicester City | - | Chelsea FC | 0:3 | ||||
| 13. Round | 28/11/2021 | Leicester City | - | Watford FC | 4:2 | ||||
| 16. Round | 12/12/2021 | Leicester City | - | Newcastle United | 4:0 | ||||
| 19. Round | 26/12/2021 | Manchester City | - | Leicester City | 6:3 | ||||
| 20. Round | 28/12/2021 | Leicester City | - | Liverpool FC | 1:0 | ||||
| 17. Round | 19/01/2022 | Leicester City | - | Tottenham Hotspur | 2:3 | ||||
| 23. Round | 23/01/2022 | Leicester City | - | Brighton & Hove Albion | 1:1 | ||||
| 24. Round | 10/02/2022 | Liverpool FC | - | Leicester City | 2:0 | ||||
| 26. Round | 20/02/2022 | Wolverhampton Wanderers | - | Leicester City | 2:1 | |
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| 22. Round | 01/03/2022 | Burnley FC | - | Leicester City | 0:2 | ||||
| 28. Round | 05/03/2022 | Leicester City | - | Leeds United | 1:0 | ||||
| 29. Round | 13/03/2022 | Arsenal FC | - | Leicester City | 2:0 | ||||
| 35. Round | 01/05/2022 | Tottenham Hotspur | - | Leicester City | 3:1 | |
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| 37. Round | 15/05/2022 | Watford FC | - | Leicester City | 1:5 |
England
