| 2. Round | 06/08/2022 | Colchester United | - | Carlisle United | 1:1 | ||||
| 3. Round | 13/08/2022 | Stockport County | - | Colchester United | 1:0 |  |
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| 4. Round | 16/08/2022 | Colchester United | - | Bradford City | 1:0 | ||||
| 5. Round | 20/08/2022 | Colchester United | - | Leyton Orient | 1:3 | ||||
| 6. Round | 27/08/2022 | Tranmere Rovers | - | Colchester United | 2:0 | ||||
| 7. Round | 03/09/2022 | Colchester United | - | Hartlepool United | 1:1 | |
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| 14. Round | 08/10/2022 | Colchester United | - | Harrogate Town | 2:1 | ||||
| 15. Round | 15/10/2022 | Swindon Town | - | Colchester United | 1:0 | |
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| 16. Round | 22/10/2022 | Newport County | - | Colchester United | 1:0 | ||||
| 13. Round | 25/10/2022 | Colchester United | - | Crawley Town | 2:2 | ||||
| 17. Round | 29/10/2022 | Colchester United | - | Stevenage FC | 1:1 |  |
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| 8. Round | 01/11/2022 | Barrow AFC | - | Colchester United | 3:1 | ||||
| 25. Round | 01/01/2023 | Colchester United | - | Swindon Town | 1:0 | ||||
| 40. Round | 07/04/2023 | Stevenage FC | - | Colchester United | 1:1 | ||||
| 42. Round | 15/04/2023 | Salford City | - | Colchester United | 0:1 | ||||
| 43. Round | 18/04/2023 | Crawley Town | - | Colchester United | 0:0 | ||||
| 46. Round | 08/05/2023 | Colchester United | - | Mansfield Town | 0:2 | |
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