| 1. Round | 14/08/2010 | Wigan Athletic | - | Blackpool FC | 0:4 |  |
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| 2. Round | 21/08/2010 | Arsenal FC | - | Blackpool FC | 6:0 | ||||
| 4. Round | 11/09/2010 | Newcastle United | - | Blackpool FC | 0:2 | ||||
| 5. Round | 19/09/2010 | Chelsea FC | - | Blackpool FC | 4:0 | ||||
| 6. Round | 25/09/2010 | Blackpool FC | - | Blackburn Rovers | 1:2 |  |
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| 8. Round | 17/10/2010 | Blackpool FC | - | Manchester City | 2:3 | |
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| 9. Round | 23/10/2010 | Birmingham City | - | Blackpool FC | 2:0 | ||||
| 11. Round | 06/11/2010 | Blackpool FC | - | Everton FC | 2:2 | ||||
| 12. Round | 10/11/2010 | Aston Villa | - | Blackpool FC | 3:2 | |
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| 13. Round | 13/11/2010 | West Ham United | - | Blackpool FC | 0:0 | ||||
| 14. Round | 20/11/2010 | Blackpool FC | - | Wolverhampton Wanderers | 2:1 | |
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| 24. Round | 22/01/2011 | Blackpool FC | - | Sunderland AFC | 1:2 | ||||
| 16. Round | 25/01/2011 | Blackpool FC | - | Manchester United | 2:3 | ||||
| 25. Round | 02/02/2011 | Blackpool FC | - | West Ham United | 1:3 | ||||
| 26. Round | 05/02/2011 | Everton FC | - | Blackpool FC | 5:3 | ||||
| 27. Round | 12/02/2011 | Blackpool FC | - | Aston Villa | 1:1 |
England