| 3. Round | 28/08/2021 | Arsenal FC [U18] | - | Brighton & Hove Albion [U18] | 2:2 | ||||
| 5. Round | 25/09/2021 | Arsenal FC [U18] | - | Birmingham City [U18] | 1:0 | ||||
| 13. Round | 08/01/2022 | Arsenal FC [U18] | - | Tottenham Hotspur [U18] | 3:2 | ||||
| 14. Round | 15/01/2022 | West Ham United [U18] | - | Arsenal FC [U18] | 3:0 | ||||
| 15. Round | 22/01/2022 | Arsenal FC [U18] | - | Chelsea FC [U18] | 4:0 | ||||
| 16. Round | 05/02/2022 | Arsenal FC [U18] | - | Leicester City [U18] | 1:1 | ||||
| 18. Round | 26/02/2022 | Arsenal FC [U18] | - | Reading FC [U18] | 4:2 |  |
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| 19. Round | 05/03/2022 | Aston Villa [U18] | - | Arsenal FC [U18] | 2:3 | ||||
| 20. Round | 12/03/2022 | Arsenal FC [U18] | - | West Bromwich Albion [U18] | 1:2 | ||||
| 21. Round | 19/03/2022 | Brighton & Hove Albion [U18] | - | Arsenal FC [U18] | 1:3 | ||||
| 22. Round | 02/04/2022 | Arsenal FC [U18] | - | Southampton FC [U18] | 4:2 | |
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| 23. Round | 09/04/2022 | Birmingham City [U18] | - | Arsenal FC [U18] | 1:1 | ||||
| 24. Round | 23/04/2022 | Arsenal FC [U18] | - | Norwich City [U18] | 2:0 | ||||
| 25. Round | 30/04/2022 | Arsenal FC [U18] | - | Fulham FC [U18] | 2:1 | ||||
| 26. Round | 07/05/2022 | Tottenham Hotspur [U18] | - | Arsenal FC [U18] | 0:5 |
Wales