2. Round | 23/08/2021 | Nottingham Forest U23 | - | Southampton FC U23 | 0:0 | ||||
3. Round | 29/08/2021 | Middlesbrough FC U23 | - | Southampton FC U23 | 2:1 | ||||
4. Round | 10/09/2021 | Fulham FC U23 | - | Southampton FC U23 | 3:0 | ||||
9. Round | 25/10/2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
15. Round | 17/12/2021 | Norwich City U23 | - | Southampton FC U23 | 4:3 | ||||
19. Round | 07/02/2022 | West Bromwich Albion U23 | - | Southampton FC U23 | 0:1 | ||||
26. Round | 01/05/2022 | Southampton FC U23 | - | Sunderland AFC U23 | 1:0 |