| 2. Round | 12/09/2021 | AEK Larnaca | - | Omonia Nikosia | 2:1 |  |
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| 3. Round | 18/09/2021 | Paphos FC | - | AEK Larnaca | 1:1 | ||||
| 4. Round | 27/09/2021 | AEK Larnaca | - | Olympiakos Nikosia | 1:0 | ||||
| 5. Round | 01/10/2021 | Apollon Limassol | - | AEK Larnaca | 1:4 | ||||
| 6. Round | 16/10/2021 | AEK Larnaca | - | PAEEK | 3:0 | ||||
| 7. Round | 25/10/2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 | |
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| 8. Round | 31/10/2021 | AEK Larnaca | - | Ethnikos Achna | 1:0 | ||||
| 9. Round | 06/11/2021 | Aris Limassol | - | AEK Larnaca | 1:0 | ||||
| 10. Round | 22/11/2021 | AEK Larnaca | - | APOEL Nikosia | 0:0 | ||||
| 11. Round | 28/11/2021 | AEL Limassol | - | AEK Larnaca | 0:2 | ||||
| 12. Round | 04/12/2021 | Doxa Katokopias | - | AEK Larnaca | 1:4 | |
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| 13. Round | 13/12/2021 | Omonia Nikosia | - | AEK Larnaca | 1:1 | ||||
| 14. Round | 20/12/2021 | AEK Larnaca | - | Paphos FC | 1:3 | ||||
| 18. Round | 24/01/2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | ||||
| 19. Round | 29/01/2022 | Ethnikos Achna | - | AEK Larnaca | 0:0 | ||||
| 20. Round | 05/02/2022 | AEK Larnaca | - | Aris Limassol | 0:0 |  |
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| 22. Round | 26/02/2022 | AEK Larnaca | - | AEL Limassol | 3:1 |
England