| 1. Round | 15/08/2021 | Tottenham Hotspur | - | Manchester City | 1:0 | ||||
| 11. Round | 07/11/2021 | Everton FC | - | Tottenham Hotspur | 0:0 | ||||
| 15. Round | 05/12/2021 | Tottenham Hotspur | - | Norwich City | 3:0 | ||||
| 20. Round | 28/12/2021 | Southampton FC | - | Tottenham Hotspur | 1:1 | ||||
| 17. Round | 19/01/2022 | Leicester City | - | Tottenham Hotspur | 2:3 | ||||
| 23. Round | 23/01/2022 | Chelsea FC | - | Tottenham Hotspur | 2:0 | ||||
| 25. Round | 13/02/2022 | Tottenham Hotspur | - | Wolverhampton Wanderers | 0:2 | ||||
| 26. Round | 19/02/2022 | Manchester City | - | Tottenham Hotspur | 2:3 | ||||
| 27. Round | 26/02/2022 | Leeds United | - | Tottenham Hotspur | 0:4 |  |
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| 28. Round | 07/03/2022 | Tottenham Hotspur | - | Everton FC | 5:0 | ||||
| 29. Round | 12/03/2022 | Manchester United | - | Tottenham Hotspur | 3:2 | ||||
| 16. Round | 16/03/2022 | Brighton & Hove Albion | - | Tottenham Hotspur | 0:2 | ||||
| 30. Round | 20/03/2022 | Tottenham Hotspur | - | West Ham United | 3:1 | ||||
| 31. Round | 03/04/2022 | Tottenham Hotspur | - | Newcastle United | 5:1 | |
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| 32. Round | 09/04/2022 | Aston Villa | - | Tottenham Hotspur | 0:4 |
Ireland
