1. Round 19/08/2000 Derby County - Southampton FC 2:2
2. Round 23/08/2000 Southampton FC - Coventry City 1:2
3. Round 26/08/2000 Southampton FC - Liverpool FC 3:3
4. Round 06/09/2000 Charlton Athletic - Southampton FC 1:1
5. Round 09/09/2000 Leicester City - Southampton FC 1:0
6. Round 16/09/2000 Southampton FC - Newcastle United 2:0
7. Round 23/09/2000 Bradford City - Southampton FC 0:1
8. Round 30/09/2000 Southampton FC - Middlesbrough FC 1:3
9. Round 14/10/2000 Everton FC - Southampton FC 1:1
10. Round 23/10/2000 Southampton FC - Manchester City 0:2
11. Round 28/10/2000 Manchester United - Southampton FC 5:0
12. Round 04/11/2000 Southampton FC - Chelsea FC 3:2
13. Round 11/11/2000 Sunderland AFC - Southampton FC 2:2
14. Round 18/11/2000 Southampton FC - Aston Villa 2:0
15. Round 25/11/2000 Southampton FC - West Ham United 2:3 Goal
16. Round 02/12/2000 Arsenal FC - Southampton FC 1:0
17. Round 09/12/2000 Southampton FC - Leeds United 1:0 yellow card
18. Round 16/12/2000 Ipswich Town - Southampton FC 3:1
21. Round 30/12/2000 Southampton FC - Derby County 1:0
22. Round 01/01/2001 Liverpool FC - Southampton FC 2:1
23. Round 13/01/2001 Southampton FC - Charlton Athletic 0:0
24. Round 20/01/2001 Tottenham Hotspur - Southampton FC 0:0
25. Round 31/01/2001 Southampton FC - Leicester City 1:0
27. Round 10/02/2001 Southampton FC - Bradford City 2:0
28. Round 24/02/2001 Middlesbrough FC - Southampton FC 0:1
29. Round 03/03/2001 Manchester City - Southampton FC 0:1
30. Round 17/03/2001 Southampton FC - Everton FC 1:0
31. Round 02/04/2001 Southampton FC - Ipswich Town 0:3
32. Round 07/04/2001 Leeds United - Southampton FC 2:0
33. Round 14/04/2001 Chelsea FC - Southampton FC 1:0
35. Round 21/04/2001 Aston Villa - Southampton FC 0:0
36. Round 28/04/2001 Southampton FC - Sunderland AFC 0:1
26. Round 01/05/2001 Newcastle United - Southampton FC 1:1
37. Round 05/05/2001 West Ham United - Southampton FC 3:0
34. Round 13/05/2001 Southampton FC - Manchester United 2:1