| 1. Round | 14/08/2021 | West Ham United [U18] | - | Reading FC [U18] | 3:1 | ||||
| 2. Round | 21/08/2021 | Reading FC [U18] | - | Fulham FC [U18] | 0:1 | ||||
| 3. Round | 28/08/2021 | Leicester City [U18] | - | Reading FC [U18] | 2:1 | ||||
| 4. Round | 11/09/2021 | Tottenham Hotspur [U18] | - | Reading FC [U18] | 3:2 | ||||
| 5. Round | 25/09/2021 | Reading FC [U18] | - | Aston Villa [U18] | 5:2 | ||||
| 6. Round | 02/10/2021 | Reading FC [U18] | - | Crystal Palace [U18] | 3:3 | ||||
| 7. Round | 23/10/2021 | Brighton & Hove Albion [U18] | - | Reading FC [U18] | 3:1 | ||||
| 8. Round | 30/10/2021 | Chelsea FC [U18] | - | Reading FC [U18] | 3:0 | ||||
| 9. Round | 06/11/2021 | Reading FC [U18] | - | Arsenal FC [U18] | 0:1 | ||||
| 10. Round | 20/11/2021 | Birmingham City [U18] | - | Reading FC [U18] | 1:3 |
England