21. Round | 11/12/2021 | Leyton Orient | - | Crawley Town | 1:2 | ||||
22. Round | 18/12/2021 | Tranmere Rovers | - | Leyton Orient | 1:0 | ||||
28. Round | 22/01/2022 | Leyton Orient | - | Port Vale FC | 0:0 | ||||
29. Round | 29/01/2022 | Mansfield Town | - | Leyton Orient | 2:0 | ||||
30. Round | 05/02/2022 | Leyton Orient | - | Colchester United | 0:1 | ||||
31. Round | 08/02/2022 | Exeter City | - | Leyton Orient | 1:0 | ||||
25. Round | 22/02/2022 | Leyton Orient | - | Bristol Rovers | 0:2 | ||||
34. Round | 26/02/2022 | Leyton Orient | - | Carlisle United | 0:1 | ||||
23. Round | 01/03/2022 | Colchester United | - | Leyton Orient | 2:2 | ||||
35. Round | 05/03/2022 | Leyton Orient | - | Stevenage FC | 2:2 | ||||
33. Round | 22/03/2022 | Harrogate Town | - | Leyton Orient | 0:3 | ||||
41. Round | 09/04/2022 | Sutton United | - | Leyton Orient | 1:0 | ||||
42. Round | 15/04/2022 | Leyton Orient | - | Scunthorpe United | 3:0 | ||||
45. Round | 30/04/2022 | Crawley Town | - | Leyton Orient | 0:2 |