| 1. Round | 07/08/2021 | Salford City | - | Leyton Orient | 1:1 |  |
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| 6. Round | 04/09/2021 | Carlisle United | - | Salford City | 2:1 | ||||
| 7. Round | 11/09/2021 | Salford City | - | Bradford City | 1:0 | ||||
| 8. Round | 18/09/2021 | Tranmere Rovers | - | Salford City | 2:0 | ||||
| 10. Round | 02/10/2021 | Colchester United | - | Salford City | 0:2 | ||||
| 11. Round | 09/10/2021 | Walsall FC | - | Salford City | 2:1 | ||||
| 12. Round | 16/10/2021 | Salford City | - | Hartlepool United | 2:0 | |
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| 13. Round | 19/10/2021 | Salford City | - | Rochdale AFC | 0:0 |  |
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| 14. Round | 23/10/2021 | Forest Green Rovers | - | Salford City | 3:1 | ||||
| 15. Round | 30/10/2021 | Salford City | - | Exeter City | 1:2 | ||||
| 18. Round | 23/11/2021 | Salford City | - | Bristol Rovers | 1:1 |  |
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| 37. Round | 15/03/2022 | Rochdale AFC | - | Salford City | 1:1 |
England