| 2. Round | 20/08/2021 | Norwich City U23 | - | Stoke City U23 | 0:1 | ||||
| 7. Round | 01/10/2021 | Southampton FC U23 | - | Stoke City U23 | 1:1 | ||||
| 12. Round | 19/11/2021 | Fulham FC U23 | - | Stoke City U23 | 3:0 | ||||
| 17. Round | 14/01/2022 | Birmingham City U23 | - | Stoke City U23 | 1:1 | ||||
| 16. Round | 25/03/2022 | Stoke City U23 | - | Norwich City U23 | 0:4 | ||||
| 24. Round | 01/04/2022 | Aston Villa U23 | - | Stoke City U23 | 1:4 |
England