| 7. Round | 11/09/2021 | Milton Keynes Dons | - | Portsmouth FC | 1:0 | ||||
| 8. Round | 18/09/2021 | Gillingham FC | - | Milton Keynes Dons | 1:4 |  |
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| 9. Round | 25/09/2021 | Milton Keynes Dons | - | Wycombe Wanderers | 1:0 | ||||
| 10. Round | 28/09/2021 | Milton Keynes Dons | - | Fleetwood Town | 3:3 | ||||
| 11. Round | 02/10/2021 | Doncaster Rovers | - | Milton Keynes Dons | 2:1 | ||||
| 13. Round | 16/10/2021 | Shrewsbury Town | - | Milton Keynes Dons | 1:0 | ||||
| 14. Round | 19/10/2021 | Wigan Athletic | - | Milton Keynes Dons | 1:2 | ||||
| 16. Round | 30/10/2021 | Crewe Alexandra | - | Milton Keynes Dons | 1:4 | |
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| 17. Round | 13/11/2021 | Milton Keynes Dons | - | Cambridge United | 4:1 | |
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| 18. Round | 20/11/2021 | Milton Keynes Dons | - | Burton Albion | 1:0 | |
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| 19. Round | 23/11/2021 | Sheffield Wednesday | - | Milton Keynes Dons | 2:1 |
England