| 1. Round | 04/09/2021 | Aston Villa WFC [Women] | - | Leicester City WFC [Women] | 2:1 | ||||
| 3. Round | 26/09/2021 | Brighton & Hove Albion WFC [Women] | - | Aston Villa WFC [Women] | 0:1 | ||||
| 4. Round | 02/10/2021 | Aston Villa WFC [Women] | - | Arsenal WFC [Women] | 0:4 | ||||
| 5. Round | 10/10/2021 | Reading WFC [Women] | - | Aston Villa WFC [Women] | 3:0 | ||||
| 6. Round | 06/11/2021 | Aston Villa WFC [Women] | - | Chelsea FC Women [Women] | 0:1 | ||||
| 7. Round | 14/11/2021 | Birmingham City WFC [Women] | - | Aston Villa WFC [Women] | 0:1 | ||||
| 8. Round | 20/11/2021 | Manchester City WFC [Women] | - | Aston Villa WFC [Women] | 5:0 | ||||
| 9. Round | 12/12/2021 | Aston Villa WFC [Women] | - | Tottenham Hotspur WFC [Women] | 1:2 | ||||
| 10. Round | 19/12/2021 | Manchester United WFC [Women] | - | Aston Villa WFC [Women] | 5:0 | ||||
| 12. Round | 15/01/2022 | Aston Villa WFC [Women] | - | Manchester City WFC [Women] | 0:3 | ||||
| 21. Round | 01/05/2022 | Arsenal WFC [Women] | - | Aston Villa WFC [Women] | 7:0 | ||||
| 22. Round | 08/05/2022 | Aston Villa WFC [Women] | - | Birmingham City WFC [Women] | 0:1 |
England