| 8. Round | 18/09/2021 | Oldham Athletic | - | Hartlepool United | 0:0 | ||||
| 9. Round | 25/09/2021 | Hartlepool United | - | Exeter City | 1:1 | ||||
| 10. Round | 02/10/2021 | Stevenage FC | - | Hartlepool United | 2:0 | ||||
| 12. Round | 16/10/2021 | Salford City | - | Hartlepool United | 2:0 | ||||
| 13. Round | 19/10/2021 | Bradford City | - | Hartlepool United | 1:3 | ||||
| 15. Round | 30/10/2021 | Leyton Orient | - | Hartlepool United | 5:0 | ||||
| 16. Round | 12/11/2021 | Hartlepool United | - | Newport County | 1:2 | ||||
| 18. Round | 23/11/2021 | Swindon Town | - | Hartlepool United | 3:1 |
Cameroon