| 1. Round | 23/08/2021 | Sampdoria | - | AC Milan | 0:1 | ||||
| 2. Round | 29/08/2021 | Sassuolo Calcio | - | Sampdoria | 0:0 | ||||
| 3. Round | 12/09/2021 | Sampdoria | - | Inter | 2:2 | ||||
| 4. Round | 19/09/2021 | Empoli FC | - | Sampdoria | 0:3 | ||||
| 5. Round | 23/09/2021 | Sampdoria | - | SSC Napoli | 0:4 |  |
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| 6. Round | 26/09/2021 | Juventus | - | Sampdoria | 3:2 | ||||
| 7. Round | 03/10/2021 | Sampdoria | - | Udinese Calcio | 3:3 | ||||
| 33. Round | 16/04/2022 | Sampdoria | - | US Salernitana 1919 | 1:2 | ||||
| 36. Round | 07/05/2022 | Lazio Roma | - | Sampdoria | 2:0 | ||||
| 37. Round | 16/05/2022 | Sampdoria | - | ACF Fiorentina | 4:1 | ||||
| 38. Round | 22/05/2022 | Inter | - | Sampdoria | 3:0 |
Denmark