| 6. Round | 21/09/2021 | Fortuna Sittard | - | AFC Ajax | 0:5 |  |
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| 7. Round | 25/09/2021 | AFC Ajax | - | FC Groningen | 3:0 | ||||
| 9. Round | 16/10/2021 | sc Heerenveen | - | AFC Ajax | 0:2 | ||||
| 10. Round | 24/10/2021 | AFC Ajax | - | PSV Eindhoven | 5:0 | ||||
| 12. Round | 07/11/2021 | AFC Ajax | - | Go Ahead Eagles | 0:0 | ||||
| 22. Round | 13/02/2022 | AFC Ajax | - | FC Twente | 5:0 | ||||
| 24. Round | 27/02/2022 | Go Ahead Eagles | - | AFC Ajax | 2:1 | ||||
| 25. Round | 06/03/2022 | AFC Ajax | - | RKC Waalwijk | 3:2 | ||||
| 26. Round | 11/03/2022 | SC Cambuur | - | AFC Ajax | 2:3 | ||||
| 28. Round | 02/04/2022 | FC Groningen | - | AFC Ajax | 1:3 | ||||
| 29. Round | 09/04/2022 | AFC Ajax | - | Sparta Rotterdam | 2:1 | ||||
| 30. Round | 23/04/2022 | NEC Nijmegen | - | AFC Ajax | 0:1 | ||||
| 31. Round | 30/04/2022 | AFC Ajax | - | PEC Zwolle | 3:0 | ||||
| 32. Round | 08/05/2022 | AZ Alkmaar | - | AFC Ajax | 2:2 | ||||
| 33. Round | 11/05/2022 | AFC Ajax | - | sc Heerenveen | 5:0 | ||||
| 34. Round | 15/05/2022 | Vitesse | - | AFC Ajax | 2:2 |
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