| 1. Round | 07/08/2021 | Stoke City | - | Reading FC | 3:2 | ||||
| 18. Round | 20/11/2021 | Stoke City | - | Peterborough United | 2:0 | ||||
| 20. Round | 27/11/2021 | Stoke City | - | Blackburn Rovers | 0:1 | ||||
| 21. Round | 05/12/2021 | Queens Park Rangers | - | Stoke City | 0:2 |  |
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| 22. Round | 11/12/2021 | Stoke City | - | Middlesbrough FC | 0:0 | ||||
| 25. Round | 30/12/2021 | Stoke City | - | Derby County | 1:2 | ||||
| 26. Round | 03/01/2022 | Stoke City | - | Preston North End | 1:2 | ||||
| 35. Round | 26/02/2022 | AFC Bournemouth | - | Stoke City | 2:1 |  |
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| 38. Round | 16/03/2022 | Cardiff City | - | Stoke City | 2:1 | ||||
| 46. Round | 07/05/2022 | Stoke City | - | Coventry City | 1:1 |
England
