| 1. Round | 15/08/2021 | Tottenham Hotspur | - | Manchester City | 1:0 | ||||
| 5. Round | 18/09/2021 | Manchester City | - | Southampton FC | 0:0 | ||||
| 8. Round | 16/10/2021 | Manchester City | - | Burnley FC | 2:0 | ||||
| 12. Round | 21/11/2021 | Manchester City | - | Everton FC | 3:0 | ||||
| 14. Round | 01/12/2021 | Aston Villa | - | Manchester City | 1:2 | ||||
| 17. Round | 14/12/2021 | Manchester City | - | Leeds United | 7:0 |  |
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| 20. Round | 29/12/2021 | Brentford FC | - | Manchester City | 0:1 | ||||
| 21. Round | 01/01/2022 | Arsenal FC | - | Manchester City | 1:2 | ||||
| 25. Round | 12/02/2022 | Norwich City | - | Manchester City | 0:4 | ||||
| 31. Round | 02/04/2022 | Burnley FC | - | Manchester City | 0:2 | ||||
| 30. Round | 20/04/2022 | Manchester City | - | Brighton & Hove Albion | 3:0 | ||||
| 34. Round | 23/04/2022 | Manchester City | - | Watford FC | 5:1 | ||||
| 35. Round | 30/04/2022 | Leeds United | - | Manchester City | 0:4 | |
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| 33. Round | 11/05/2022 | Wolverhampton Wanderers | - | Manchester City | 1:5 |
Netherlands
Ivory Coast 
