| 14. Round | 06/12/2021 | Newcastle United U23 | - | Sunderland AFC U23 | 2:0 |  |
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| 17. Round | 14/01/2022 | Reading FC U23 | - | Newcastle United U23 | 1:4 | ||||
| 18. Round | 24/01/2022 | Newcastle United U23 | - | Nottingham Forest U23 | 0:1 | ||||
| 13. Round | 31/01/2022 | Newcastle United U23 | - | Aston Villa U23 | 2:0 | ||||
| 20. Round | 21/02/2022 | Newcastle United U23 | - | Fulham FC U23 | 1:6 | ||||
| 22. Round | 14/03/2022 | Newcastle United U23 | - | Birmingham City U23 | 1:0 | ||||
| 23. Round | 21/03/2022 | Stoke City U23 | - | Newcastle United U23 | 2:1 | |
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| 16. Round | 28/03/2022 | Newcastle United U23 | - | West Bromwich Albion U23 | 4:3 | ||||
| 24. Round | 01/04/2022 | Middlesbrough FC U23 | - | Newcastle United U23 | 4:2 | |
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| 19. Round | 08/04/2022 | Burnley FC U23 | - | Newcastle United U23 | 5:1 | ||||
| 25. Round | 25/04/2022 | Newcastle United U23 | - | Southampton FC U23 | 2:4 | ||||
| 26. Round | 02/05/2022 | Aston Villa U23 | - | Newcastle United U23 | 1:2 | |
England