| 16. Round | 06/01/2010 | PAS Giannina | - | Skoda Xanthi | 0:0 | ||||
| 17. Round | 09/01/2010 | Skoda Xanthi | - | Panathinaikos | 1:2 | ||||
| 18. Round | 16/01/2010 | Skoda Xanthi | - | Ergotelis | 1:0 |  |
 |
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| 19. Round | 24/01/2010 | Panthrakikos | - | Skoda Xanthi | 1:1 | ||||
| 20. Round | 31/01/2010 | Skoda Xanthi | - | Aris Saloniki | 2:1 | |
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| 21. Round | 06/02/2010 | AEK Athen | - | Skoda Xanthi | 3:1 | ||||
| 22. Round | 13/02/2010 | Skoda Xanthi | - | AE Lárissa | 0:1 | ||||
| 24. Round | 27/02/2010 | Skoda Xanthi | - | PAOK Saloniki | 0:3 | ||||
| 29. Round | 11/04/2010 | Skoda Xanthi | - | Atromitos | 2:1 | |
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| 30. Round | 18/04/2010 | Iraklis Saloniki | - | Skoda Xanthi | 2:4 | |
England
Jamaica