| 1. Round | 30/07/2022 | Tranmere Rovers | - | Stevenage FC | 1:2 | ||||
| 2. Round | 06/08/2022 | Mansfield Town | - | Tranmere Rovers | 1:0 | ||||
| 3. Round | 13/08/2022 | Tranmere Rovers | - | Gillingham FC | 3:0 | ||||
| 4. Round | 16/08/2022 | Hartlepool United | - | Tranmere Rovers | 0:0 | ||||
| 5. Round | 20/08/2022 | Newport County | - | Tranmere Rovers | 2:1 | ||||
| 6. Round | 27/08/2022 | Tranmere Rovers | - | Colchester United | 2:0 |  |
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| 7. Round | 03/09/2022 | Leyton Orient | - | Tranmere Rovers | 2:0 | |
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| 9. Round | 13/09/2022 | Tranmere Rovers | - | Bradford City | 1:2 | |
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| 10. Round | 17/09/2022 | Salford City | - | Tranmere Rovers | 0:1 | ||||
| 12. Round | 01/10/2022 | Tranmere Rovers | - | Barrow AFC | 1:0 | ||||
| 19. Round | 19/11/2022 | Tranmere Rovers | - | AFC Wimbledon | 0:2 | ||||
| 20. Round | 03/12/2022 | Northampton Town | - | Tranmere Rovers | 0:0 | ||||
| 21. Round | 10/12/2022 | Grimsby Town | - | Tranmere Rovers | 2:1 |
Ireland