| 1. Round | 07/08/2021 | Exeter City | - | Bradford City | 0:0 |  |
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| 2. Round | 14/08/2021 | Leyton Orient | - | Exeter City | 3:0 | ||||
| 3. Round | 17/08/2021 | Barrow AFC | - | Exeter City | 0:0 | ||||
| 4. Round | 21/08/2021 | Exeter City | - | Bristol Rovers | 4:1 | ||||
| 6. Round | 04/09/2021 | Exeter City | - | Forest Green Rovers | 0:0 | ||||
| 7. Round | 11/09/2021 | Scunthorpe United | - | Exeter City | 0:4 | ||||
| 8. Round | 18/09/2021 | Exeter City | - | Sutton United | 2:0 | ||||
| 9. Round | 25/09/2021 | Hartlepool United | - | Exeter City | 1:1 | ||||
| 10. Round | 02/10/2021 | Exeter City | - | Walsall FC | 2:2 | ||||
| 11. Round | 09/10/2021 | Stevenage FC | - | Exeter City | 2:2 | |
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| 13. Round | 19/10/2021 | Crawley Town | - | Exeter City | 1:3 |  |
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| 15. Round | 30/10/2021 | Salford City | - | Exeter City | 1:2 | ||||
| 16. Round | 13/11/2021 | Exeter City | - | Oldham Athletic | 2:1 | |
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| 32. Round | 12/02/2022 | Bradford City | - | Exeter City | 0:1 | ||||
| 26. Round | 15/02/2022 | Exeter City | - | Harrogate Town | 4:3 | ||||
| 38. Round | 19/03/2022 | Oldham Athletic | - | Exeter City | 0:2 | |
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France
Cameroon