| 4. Round | 04/10/2020 | Willem II | - | Feyenoord | 1:4 | ||||
| 5. Round | 17/10/2020 | Willem II | - | FC Twente | 0:3 | ||||
| 6. Round | 24/10/2020 | PEC Zwolle | - | Willem II | 0:0 | ||||
| 8. Round | 08/11/2020 | PSV Eindhoven | - | Willem II | 3:0 | ||||
| 9. Round | 21/11/2020 | Willem II | - | VVV-Venlo | 2:1 | ||||
| 14. Round | 23/12/2020 | Willem II | - | AFC Ajax | 1:1 | ||||
| 15. Round | 10/01/2021 | VVV-Venlo | - | Willem II | 2:1 | ||||
| 20. Round | 31/01/2021 | Willem II | - | FC Emmen | 2:0 | ||||
| 22. Round | 14/02/2021 | Feyenoord | - | Willem II | 5:0 | ||||
| 21. Round | 24/02/2021 | Willem II | - | ADO Den Haag | 1:1 | ||||
| 27. Round | 21/03/2021 | Vitesse | - | Willem II | 0:0 |
Netherlands