| 1. Round | 30/07/2022 | Rochdale AFC | - | Crewe Alexandra | 1:2 | ||||
| 2. Round | 06/08/2022 | Crewe Alexandra | - | Harrogate Town | 3:0 | ||||
| 3. Round | 13/08/2022 | Salford City | - | Crewe Alexandra | 3:0 | ||||
| 4. Round | 16/08/2022 | Crewe Alexandra | - | Sutton United | 1:0 | ||||
| 15. Round | 14/10/2022 | Tranmere Rovers | - | Crewe Alexandra | 3:0 | ||||
| 16. Round | 22/10/2022 | Crewe Alexandra | - | Doncaster Rovers | 1:1 | ||||
| 13. Round | 25/10/2022 | AFC Wimbledon | - | Crewe Alexandra | 1:1 | ||||
| 18. Round | 12/11/2022 | Crewe Alexandra | - | Colchester United | 1:0 | ||||
| 23. Round | 26/12/2022 | Stockport County | - | Crewe Alexandra | 2:0 |
England