| 9. Round | 25/10/2021 | Newcastle United U23 | - | Wolverhampton Wanderers U23 | 2:3 | ||||
| 10. Round | 01/11/2021 | Stoke City U23 | - | Wolverhampton Wanderers U23 | 2:0 | ||||
| 11. Round | 05/11/2021 | Wolverhampton Wanderers U23 | - | West Bromwich Albion U23 | 1:1 | ||||
| 12. Round | 19/11/2021 | Birmingham City U23 | - | Wolverhampton Wanderers U23 | 1:2 |  |
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| 14. Round | 03/12/2021 | Fulham FC U23 | - | Wolverhampton Wanderers U23 | 4:2 | ||||
| 18. Round | 24/01/2022 | Sunderland AFC U23 | - | Wolverhampton Wanderers U23 | 1:2 | ||||
| 19. Round | 07/02/2022 | Wolverhampton Wanderers U23 | - | Birmingham City U23 | 2:0 | ||||
| 23. Round | 18/03/2022 | Wolverhampton Wanderers U23 | - | Aston Villa U23 | 3:0 | ||||
| 16. Round | 25/03/2022 | Southampton FC U23 | - | Wolverhampton Wanderers U23 | 2:4 |  |
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| 20. Round | 15/04/2022 | Middlesbrough FC U23 | - | Wolverhampton Wanderers U23 | 0:3 | ||||
| 15. Round | 18/04/2022 | Wolverhampton Wanderers U23 | - | Newcastle United U23 | 4:2 | ||||
| 26. Round | 29/04/2022 | Norwich City U23 | - | Wolverhampton Wanderers U23 | 0:2 |
England