| 5. Round | 19/09/2021 | Southampton FC U23 | - | Burnley FC U23 | 0:2 | ||||
| 17. Round | 17/01/2022 | Southampton FC U23 | - | Fulham FC U23 | 2:1 | ||||
| 18. Round | 23/01/2022 | Southampton FC U23 | - | Middlesbrough FC U23 | 1:0 | ||||
| 20. Round | 21/02/2022 | Southampton FC U23 | - | Birmingham City U23 | 2:3 | ||||
| 21. Round | 26/02/2022 | Southampton FC U23 | - | Nottingham Forest U23 | 4:2 | ||||
| 22. Round | 11/03/2022 | Aston Villa U23 | - | Southampton FC U23 | 2:2 |
England