| 1. Round | 08/08/2022 | Nottingham Forest U21 | - | Southampton FC U21 | 1:3 | ||||
| 3. Round | 19/08/2022 | Stoke City U21 | - | Southampton FC U21 | 0:3 | ||||
| 4. Round | 26/08/2022 | Southampton FC U21 | - | Norwich City U21 | 1:1 | ||||
| 8. Round | 08/10/2022 | Southampton FC U21 | - | Aston Villa U21 | 2:0 | ||||
| 9. Round | 23/10/2022 | Newcastle United U21 | - | Southampton FC U21 | 3:2 | ||||
| 11. Round | 07/11/2022 | Sunderland AFC U21 | - | Southampton FC U21 | 1:3 | ||||
| 12. Round | 06/01/2023 | Southampton FC U21 | - | Derby County U21 | 3:0 | ||||
| 14. Round | 27/01/2023 | Middlesbrough FC U21 | - | Southampton FC U21 | 2:2 | ||||
| 15. Round | 10/02/2023 | Southampton FC U21 | - | Sunderland AFC U21 | 2:2 |  |
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| 16. Round | 20/02/2023 | West Bromwich Albion U21 | - | Southampton FC U21 | 1:2 | ||||
| 18. Round | 03/03/2023 | Southampton FC U21 | - | Nottingham Forest U21 | 0:2 | ||||
| 19. Round | 17/03/2023 | Aston Villa U21 | - | Southampton FC U21 | 1:2 | ||||
| 5. Round | 31/03/2023 | Derby County U21 | - | Southampton FC U21 | 1:3 | ||||
| 21. Round | 14/04/2023 | Southampton FC U21 | - | Stoke City U21 | 2:0 | ||||
| 22. Round | 23/04/2023 | Norwich City U21 | - | Southampton FC U21 | 2:5 |
England