| 1. Round | 16/08/2021 | Sunderland AFC U23 | - | Fulham FC U23 | 3:4 | ||||
| 3. Round | 27/08/2021 | Sunderland AFC U23 | - | Norwich City U23 | 3:4 | ||||
| 4. Round | 10/09/2021 | Birmingham City U23 | - | Sunderland AFC U23 | 1:0 |  |
|||
| 5. Round | 20/09/2021 | Sunderland AFC U23 | - | Middlesbrough FC U23 | 1:3 | |
|||
| 6. Round | 27/09/2021 | Wolverhampton Wanderers U23 | - | Sunderland AFC U23 | 1:3 | |
|||
| 9. Round | 22/10/2021 | Aston Villa U23 | - | Sunderland AFC U23 | 2:3 | ||||
| 10. Round | 01/11/2021 | Reading FC U23 | - | Sunderland AFC U23 | 0:3 | ||||
| 12. Round | 21/11/2021 | Sunderland AFC U23 | - | Southampton FC U23 | 3:2 | |
England