| 5. Round | 18/09/2021 | Manchester City U23 | - | Crystal Palace U23 | 4:2 | ||||
| 6. Round | 25/09/2021 | Manchester City U23 | - | Arsenal FC U23 | 2:2 | ||||
| 7. Round | 02/10/2021 | Manchester City U23 | - | Derby County U23 | 1:0 | ||||
| 8. Round | 16/10/2021 | Manchester City U23 | - | Leicester City U23 | 5:0 |  |
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| 9. Round | 23/10/2021 | Manchester City U23 | - | Tottenham Hotspur U23 | 1:3 | ||||
| 10. Round | 29/10/2021 | Brighton & Hove Albion U23 | - | Manchester City U23 | 1:1 | ||||
| 13. Round | 29/11/2021 | Manchester City U23 | - | Leeds United U23 | 3:2 | ||||
| 15. Round | 17/12/2021 | Manchester City U23 | - | Brighton & Hove Albion U23 | 3:1 |
Spain